Australian New Crops Web Site
Supported by the Rural Industries Research and Development Corporation

Listing of Interesting Plants of the World

Huperzia serrata

Popularity of Huperzia serrata over time

[Plots of numbers of papers mentioning Huperzia serrata (filled column histogram and left hand axis scale) and line of best fit, 1926 to 2006 (complete line, with equation and % variation accounted for, in box on the left hand side); Plots of a proportional micro index, derived from numbers of papers mentioning Huperzia serrata as a proportion (scaled by multiplying by one million) of the total number of papers published for that year (broken line frequency polygon and right hand scale) and line of best fit, 1926 to 2006 (broken line, with equation and % variation accounted for, in broken line box on the right hand side)]

Total Mentions (Biological Abstracts/Biosis Previews):

References

 

Haviv H, Wong DM, Silman I, Sussman JL (2007) Bivalent ligands derived from huperzine a as acetylcholinesterase inhibitors. Current Topics in Medicinal Chemistry 7, 375-87. Contact: Sussman, J. L.; Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

 

He X-C, Feng S, Wang Z-F, Shi Y, Zheng S, Xia Y, Jiang H, Tang X-C, Bai D (2007) Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorganic & Medicinal Chemistry 15, 1394-408. Contact: He, Xu-Chang ; Chinese Acad Sci, Shanghai Inst Mat Med, Dept Synth Drugs, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China

 

Toribio A, Delannay E, Richard B, Ple K, Zeches-Hanrot M, Nuzillard J-M, Renault J-H (2007) Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography. Journal of Chromatography A 1140, 101-6. Contact: Renault, Jean-Hugues; Univ Reims, CNRS, FRE 2715, IFR 53, Bat 18,Moulin Housse,BP 1039, F-51687 Reims 2, France

 

Wang ZF, Tang XC (2007) Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury. FEBS Letters 581, 596-602. Contact: Tang, Xi Can; Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

 

Wanibuchi K, Zhang P, Abe T, Morita H, Kohno T, Chen G, Noguchi H, Abe I (2007) An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata. FEBS Journal 274, 1073-82. Contact: Abe, Ikuro; Sch Pharmaceut Sci, 52-1 Yada, Shizuoka 4228526, Japan

 

Zhang A, Neumeyer JL (2007) Receptor dimerization and bivalent ligands, an emerging topic for drug design. Current Topics in Medicinal Chemistry 7. Contact: Zhang, Ao ; Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Lu, Shanghai 201203, Peoples R China

 

Chu D, Liu W, Li Y, Li P, Gu J, Liu K (2006) Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. Planta Medica 72, 552-5. Contact: Liu, Ke; Yantai Univ, Sch Pharm, 32 Qingquan Rd, Shandong 264005, Peoples R China

 

Chua TK, Koh HL (2006) Medicinal plants as potential sources of lead compounds with anti-platelet and anti-coagulant activities. Mini-Reviews in Medicinal Chemistry 6, 611-24. Contact: Koh, H. L.; Natl Univ Singapore, Dept Pharm, 18 Sci Dr 4, Singapore 117543, Singapore

 

Li X, Ma R, Su H, Sun H, Ma G, Su Z, Zha S (2006) Rapid purification of huperzine A and B with two polystyrene based resins by preparative low-pressure liquid chromatography. Journal of Liquid Chromatography & Related Technologies 29, 569-82. Contact: Ma, Runyu ; Beijing Univ Chem Technol, Minist Educ, Key Lab Sci and Technol Controllable Chem React, Beijing 100029, Peoples R China

 

Ma X, Tan C, Zhu D, Gang DR (2006) A survey of potential huperzine A natural resources in China: The Huperziaceae. Journal of Ethnopharmacology 104, 54-67. Contact: Ma, Xiaoqiang ; Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

 

Pan J, Jin R, Hu X (2006) Application of L-amino acid in determination of Huperzine A by high performance liquid chromatography. Journal of Chromatography B 836, 108-10. Contact: Jin, Risheng ; Hefei Univ Technol, Key Lab Bioproc, Minist Educ, 193 Tunxi Rd, Hefei 230009, Anhui, Peoples R China

 

Schachter SC, White HS, Murphree L, Stables J (2006) Anticonvulsant activity of huperzine A, an alkaloid extract of Chinese club moss (Huperzia serrata), in the 6-Hz model of psychomotor seizures. Epilepsia 47, 319-20. Contact: Schachter, Steven C. ; Univ Utah, Salt Lake City, UT USA

 

Wang R, Yan H, Tang X-c (2006) Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacologica Sinica 27, 1-26. Contact: Tang, Xi-can; Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

 

Wu Q, Gu Y (2006) Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS. Journal of Pharmaceutical and Biomedical Analysis 40, 993-8. Contact: Gu, Yuehua; Univ Sci and Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

 

Yan H, Tang X-c (2006) Review on clinical application of huperzine A in China. Zhongguo Xinyao yu Linchuang Zazhi 25, 682-8. Contact: Yan Han ; Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

 

Ben Hameda A, Elosta S, Havel J (2005) Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks. Journal of Chromatography A 1084, 7-12. Contact: Ben Hameda, A. ; Masaryk Univ, Fac Sci, Dept Analyt Chem, Kotlarska 2, CZ-61137 Brno, Czech Republic

 

Fang F, Guo S-L, Li P-L, Lu W-G (2005) Content determination of assemble alkaloids of huperzine in Huperziaceae and dedentred correspondence analysis based on their UV spectra. Wuhan Zhiwuxue Yanjiu 23, 606-9. Contact: Fang Fang ; Zhejiang Normal Univ, Coll Chem and Life Sci, Jinhua 321004, Zhejiang, Peoples R China

 

Gu Y-h, Wu Q-q (2005) HPLC method for the determination of huperzine A in Huperzia serrata. Zhongguo Yaolixue Tongbao 21, 1017-8. Contact: Gu Yue-hua ; Univ Sci and Technol China, Sch Life Sci, Hefei 230027, Peoples R China

 

Li X-N, Sun H-H, Zhang G-F, Bi J-X, Ma G-H, Ma R-Y, Su Z-G (2005) A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales. Journal of Separation Science 28, 2363-9. Contact: Su, Zhi-Guo; Beijing Univ Chem Technol, Coll Life Sci, Dept Pharmaceut Engn, Beijing, Peoples R China

 

Ma X, Tan C, Zhu D, Gang DR (2005) Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of huperziaceae species in China. Journal of Agricultural and Food Chemistry 53, 1393-87. Contact: Ma, Xiaoqiang ; Univ Arizona, Dept Plant Sci, 303 Forbes Bldg, Tucson, AZ 85721 USA

 

Wang R, Tang XC (2005) Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. NeuroSignals 14, 71-82. Contact: Tang, Xi Can; Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China

 

White HS, Schachter S, Lee D, Ji X, Eisenberg D (2005) Anticonvulsant activity of Huperzine A, an alkaloid extract of Chinese club moss (Huperzia serrata). Epilepsia 46. Contact: White, H. Steve ; Univ Utah, Salt Lake City, UT USA

 

Lee IYC, Hong JY, Jung MH, Lee HW (2004) Synthesis of huperzine B through ring closing metathesis. Tetrahedron Letters 45, 285-7. Contact: Lee, Ihl Young Choi ; Korea Research Institute of Chemical Technology, Daejeon, 305-600, South Korea

 

Quan D, Wang Y (2004) A novel treatment for Alzheimer's disease - Huperzine A transdermal delivery system. Neurobiology of Aging 25, S196-S7. Contact: Quan, Danyi ; Xel Herbaceut Inc, Salt Lake City, UT USA

 

Yuan S-q, Zhao Y-M, Feng R (2004) Structural identification of huperzinine C. Yaoxue Xuebao 39, 116-8. Contact: Yuan Shan-qin ; Zhao Yi-Min ; Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, 100850, China

 

Fayuk DA, Yakel JL (2003) Regulation of nicotinic acetylcholine receptors by CHO linesterase inhibitors in rat hippocampal interneurons. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003. Contact: Fayuk, D. A. ; Yakel, J. L.; Lab. of Signal Transduction, NIEHS/NIH, RTP, NC, USA

 

Jacknowitz AI, Tracy TS (2003) Huperzine. In 'Dietary supplements: Toxicology and clinical pharmacology' pp. 245-52. (Humana Press Inc.)

 

Jin G, Luo X, He X, Jiang H, Zhang H, Bai D (2003) Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A. Arzneimittel-Forschung 53, 753-7. Contact: Bai, Donglu; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zahnjiang Hi-Tech Park, Shanghai, 20/203, China

 

Peavy GM, Jacobson MW, Hamilton JM, Sepp AN, Corey-Bloom J (2003) The effects of huperzine A on cognitive functioning and behavior in patients with Huntington's disease. Annals of Neurology 54. Contact: Peavy, Guerry M. ; La Jolla, CA, USA

 

Tan C-H, Ma X-Q, Zhou H, Jiang S-H, Zhu D-Y (2003) Two novel hydroperoxylated Lycopodium alkaloids from Huperzia serrata. Acta Botanica Sinica 45, 118-21. Contact: Zhu Da-Yuan; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

 

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han Y-F, Pang Y-P, Silman I, Sussman JL (2003) Acetylcholinesterase complexed with bivalent ligands related to Huperzine A: Experimental evidence for species-dependent protein-ligand complementarity. Journal of the American Chemical Society 125, 363-73. Contact: Sussman, Joel L.; Department of Structural Biology, Weizmann Institute of Science, Rehovot, 76100, Israel

 

Yang QP, Kou XL, Fugal KB, McLaughlin JL (2003) Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection. Phytomedicine (Jena) 10, 200-5. Contact: Kou, X. L. ; Department of Research and Development, Nature's Sunshine Products, 1655 N. Main St., Spanish Fork, UT, 84660, USA

 

Yuan S-q, Zhao Y-M (2003) A novel phlegmariurine type alkaloid from Huperzia serrata (Thunb.) Trev. Yaoxue Xuebao 38, 596-8. Contact: Yuan Shan-qin ; Zhao Yi-Min; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China

 

Zangara A (2003) The psychopharmacology of huperzine A: An alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacology Biochemistry and Behavior 75, 675-86. Contact: Zangara, Andrea; Cogintive Drug Research, 24 Portman Road, CDR House, Reading, RG30 1EA, UK

 

Zhou H, Jiang S-h, Tan C-H, Wang B-D, Zhu D-y (2003) New epoxyserratanes from Huperzia serrata. Planta Medica 69, 91-4. Contact: Zhu, Da-yuan; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, 200031, China

 

Filliat P, Foquin A, Lallement G (2002) Effects of chronic administration of huperzine A on memory in guinea pigs. Drug and Chemical Toxicology an International Journal for Rapid Communication 25, 9-24. Contact: Filliat, Pierre ; Unite de Neuropharmacologie, CRSSA, 24, Avenue des Maquis du Gresivaudan, 38702, La Tronche Cedex, France

100437.201@compuserve.com

 

Lee IYC, Jung MH, Lee HW, Yang JY (2002) Synthesis of huperzine intermediates via Mn(III)-mediated radical cyclization. Tetrahedron Letters 43, 2407-9. Contact: Lee, Ihl Young Choi ; Korea Research Institute of Chemical Technology, Taejon, 305-600, South Korea

iychoi@pado.krict.re.kr

 

Rajendran V, Saxena A, Doctor BP, Kozikowski AP (2002) Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B. Bioorganic and Medicinal Chemistry Letters 12, 1521-3. Contact: Kozikowski, Alan P.; Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC, 20007-2197, USA

kozikowa@georgetown.edu

 

Tan C-H, Wang B-D, Jiang S-h, Zhu D-y (2002) New lycopodium alkaloids from Huperzia serrata. Planta Medica 68, 188-90. Contact: Zhu, Da-yuan; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, 200031, China

dyzhu@mail.shcnc.ac.cn

 

Wang LS, Zhou J, Shao XM, Tang XC (2002) Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Research 949, 162-70. Contact: Tang, Xi Can; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-yuan Road, Shanghai, 200031, China

xctang@mail.shcnc.ac.cn

 

Xiao XQ, Zhang HY, Tang XC (2002) Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. Journal of Neuroscience Research 67, 30-6. Contact: Tang, Xi Can; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Tai-yuan Road, Shanghai, 200031, China

xctang@mail.shcnc.ac.cn

 

Yuan S-q, Zhao Y-M, Feng R (2002) Structural identification of neohuperzinine. Yaoxue Xuebao 37, 946-9. Contact: Yuan Shan-qin ; Zhao Yi-Min ; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China

 

Chang H-M, Wang J-C (2001) Confirmation of three species of pteridophytes in Taiwan. Taiwania 46, 376-84. Contact: Wang, Jenn-Che; Department of Biology, National Taiwan Normal University, Wenshan, Taipei, 116, Taiwan

biofv017@scc.ntnu/edu.tw

 

Gordon RK, Nigam SV, Weitz JA, Dave JR, Doctor BP, Ved HS (2001) The NMDA receptor ion channel: A site for binding of Huperzine A. Journal of Applied Toxicology 21, S47-S51. Contact: Gordon, Richard K. ; Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC, 20307-5100, USA

Richard.Gordon@na.amedd.army.mil

 

Tonduli LS, Testylier G, Masqueliez C, Lallement G, Monmaur P (2001) Effects of huperzine used as pre-treatment against soman-induced seizures. Neurotoxicology (Little Rock) 22, 29-37. Contact: Tonduli, L. S. ; Centre de Recherches du Service Sante des Armees, 24, Avenue des Maquis du Gresivaudan, 38 702, La Tronche Cedex, France

laura.tonduli2@freesbee.fr

 

Wang R, Xiao XQ, Tang XC (2001) Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 12, 2629-34. Contact: Tang, Xi Can; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai, 200031, China

 

Ye L, Qi J-S, Qiao J-T (2001) Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors. Neuroscience Letters 300, 145-8. Contact: Qiao, Jian-Tian; Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi, 030001, China

qiaojt@public.ty.sx.cn

 

Zhou J, Fu Y, Tang XC (2001) Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport 12, 2073-7. Contact: Tang, Xi Can; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-yuan Road, Shanghai, 200031, China

 

Gao W, Li Y, Jiang S, Zhu D (2000) Three lycopodium alkaloid N-oxides from Huperzia serrata. Planta Medica 66, 664-7. Contact: Zhu, Dayuan; State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, 20003, China

dyzhu@mail.shcnc.ac.cn

 

Mantle D, Pickering AT, Perry EK (2000) Medicinal plant extracts for the treatment of dementia: A review of their pharmacology, efficacy and tolerability. CNS Drugs 13, 201-13. Contact: Mantle, David ; Neurochemistry Department, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK

 

Tan C-H, Jiang S-H, Zhu D-Y (2000) Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata. Tetrahedron Letters 41, 5733-6. Contact: Zhu, Da-Yuan; State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, 200031, China

 

Zhou G-C, Zhu D-Y (2000) Synthesis of 5-substituted analogues of huperzine A. Bioorganic and Medicinal Chemistry Letters 10, 2055-7. Contact: Zhu, Da-Yuan; State Key Laboratory for Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Tai-yuan Road, Shanghai, 200031, China

 

Sun Q-Q, Xu S-S, Pan J-L, Guo H-M, Cao W-Q (1999) Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta Pharmacologica Sinica 20, 601-3. Contact: Xu Si-Sun ; Zhejiang Mental Health Institute, Hangzhou, 311122, China

 

Zhao H-W, Li X-Y (1999) Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells. Acta Pharmacologica Sinica 20, 941-3. Contact: Li, Xiao-Yu; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China

 

Liu D, Jiang H, Wang Q, Chen K, Ji R (1998) Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method. Bioorganic and Medicinal Chemistry Letters 8, 419-22. Contact: Chen, Kaixian ; Shanghai Inst. Materia Medica, Chin. Acad. Sci., 294 TaiYuan Rd., Shanghai 200031, China

 

Ma Y-X, Zhu Y, Yue-Di G, Zhen-Yan Y, Sai-Mei Y, Yong-Zhen Y (1998) Double-blind trial of huperzine-A (HUP) on cognitive deterioration in 314 cases of benign senescent forgetfulness, vascular dementia and Alzheimer's disease. In 'Annals of the New York Academy of Sciences; Towards prolongation of the healthy life span: Practical approaches to intervention' pp. 506-7. (New York Academy of Sciences {a})

 

Wang B-D, Jiang S-H, Gao W-Y, Zhu D-Y, Kong X-M, Yang Y-Q (1998) Structural identification of huperzine G. Acta Botanica Sinica 40, 842-5. Contact: Zhu, Da-Yuan ; State Key Lab. New Drug Res., Shanghai Inst. Materia Med., Chinese Acad. Sci., Shanghai 200031, China

 

Dong ZJ, Lo YL, Chan KY, Han YF (1996) Comparative studies of huperzine A and tacrine on scopolamine-induced amnesia of shuttle-box active avoidance in adult and aged rats. Society for Neuroscience Abstracts 22. Contact: Dep. Biochem., Hong Kong Univ. Sci. Technol., Hong Kong

 

Kozikowski AP, Ding Q, Saxena A, Doctor BP (1996) Synthesis of (racemic)-10,10-dimethylhuperzine A - A huperzine analogue possessing a slower enzyme off-rate. Bioorganic and Medicinal Chemistry Letters 6, 259-62. Contact: Kozikowski, Alan P. ; Georgetown Univ. Med. Cent., Inst. Cognitive Computational Sci., 3970 Reservoir Rd. NW, Washington, DC 20007-2197, USA

 

Madhusoodanan PV, Rajasree T, Leena KR (1996) Club mosses (Lycopodium sensu lato) of Western Ghats South India. Indian Fern Journal 13, 67-74. Contact: Dep. Bot., Univ. Calicut, 673 635 Kerala, India

 

Tang X-C (1996) Huperzine A (Shuangyiping): A promising drug for Alzheimer's disease. Acta Pharmacologica Sinica 17, 481-4. Contact: Dep. Pharmacol., State Key Lab. of Drug Res., Shanghai Inst. Materia Medica, Chinese Acad. Sci., Shanghai 200031, China

 

Xu ZR, He XC, Bai DL (1996) Studies on analogues of huperzine A for treatment of senile dementia II synthesis of analogues of (racemic) dinor huperzine A. Yaoxue Xuebao 31, 258-66. Contact: Shanghai Inst. Materia Medica, Chinese Acad. Sci., Shanghai 200031, China

 

Xu ZR, He XC, Bai DL (1996) Studies on analogues of huperzine A III. Synthesis of N-methyl pyridone analogues of huperzine A. Yaoxue Xuebao 31, 364-70. Contact: Shanghai Inst. Materia Med., Chinese Acad. Sci., Shanghai 200031, China

 

Yeung OY, Han YF (1996) Reversal effects of huperzine A and tacrine on memory deficits in bilateral NBM lesioned rats. Society for Neuroscience Abstracts 22. Contact: Dep. Biochem., Hong Kong Univ. Sci. Technol., Hong Kong

 

Zhu D-Y, Bai D-L, Tang X-C (1996) Recent studies on traditional Chinese medicinal plants. Drug Development Research 39, 147-57. Contact: Zhu, Da-Yuan ; Shanghai Inst. Materia Med., Chinese Acad. Sci., Shanghai 200031, China

 

Ruyun J (1995) Studies on molecular modification of novel constituents of chinese medicinal plants. Medicinal Chemistry Research 5, 587-94. Contact: Shanghai Inst. Materia Med., Chinese Academy Sciences, Shanghai 200031, China

 

Tiwari R (1995) Correction of PREVIEWS 98572415. International symposium on global challenges in drug development: A report (Lucknow, India, December 16-18, 1994). Addition of systematic codes. Current Research on Medicinal and Aromatic Plants 17, 213-4. Contact: Cent. Inst. Med. Aromatic Plants, Lucknow 226 015, India

 

Tiwari R (1995) International symposium on global challenges in drug development: A report (Lucknow, India, December 16-18, 1994). Current Research on Medicinal and Aromatic Plants 17, 213-4. Contact: Cent. Inst. Med. and Aromatic Plants, Lucknow 226 015, India

 

Xiong Z-Q, Tang X-C, Lin J-L, Zhu D-Y (1995) Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment. Acta Pharmacologica Sinica 16, 21-5. Contact: Tang, Xi-Can ; Dep. Pharmacol., Shanghai Inst. Materia Medica, Chinese Acad. Sci., Shanghai 200031, China

 

Yeung OY, Xiong ZO, Tang XC, Han YF (1995) Comparison of memory-enhancing effects of Huperzine A and tacrine on the radial maze performance of scopolamine-treated rats. Society for Neuroscience Abstracts 21. Contact: Yeung, O. Y. ; Dep. Biochem., Hong Kong Univ. Sch. Technol., Kowloon, Hong Kong

 

Zhu XD, Giacobini E (1995) Second generation cholinesterase inhibitors: Effect of (L)-Huperzine-A on cortical biogenic amines. Journal of Neuroscience Research 41, 828-35. Contact: Zhu, X.-D. ; Dep. Pharmacol., 1222, Southern Ill. Univ. Sch. Med., P.O. Box 19230, Springfield, IL 62794-9230, USA

 

Tang X-C, Kindel GH, Kozikowski AP, Hanin I (1994) Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. Journal of Ethnopharmacology 44, 147-55. Contact: Hanin, Israel; Dep. Pharmacology Experimental Therapeutics, Loyola Univ. Chicago, Stritch Sch. Med., 2160 South First Ave., Maywood, IL 60153, USA

 

Tang X-C, Hong X, Feng J, Zhou T-X, Liu J-S (1994) Effect of cholinesterase inhibition in vitro by huperzine analogs. Acta Pharmacologica Sinica 15, 107-10. Contact: Tang, Xi-Can ; Dep. Pharmacology, Shanghai Institute Materia Medica, Chinese Academy Sciences, Shanghai 200031, China

 

Zhang G-B, Wang M-Y, Zheng J-Q, Tang X-C (1994) Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro. Acta Pharmacologica Sinica 15, 158-61. Contact: Wang, Meng-Ya ; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu 241001, China

 

Zhu D-Y, Jiang S-H, Huang M-F, Lin L-Z, Cordell GA (1994) Huperserratinine from Huperzia serrata. Phytochemistry (Oxford) 36, 1069-72. Contact: Cordell, Geoffrey A.; Program Collaborative Res. Pharm. Sci., Dep. Med. Chem. Pharm., Coll. Pharm., Univ. Illinois Chicago, Chicago, IL 60612, USA

 

Zhou B-N, Zhu D-Y, Huang M-F, Lin L-J, Lin L-Z, Xue Yi H, Cordell GA (1993) NMR assignments of huperzine A, serratinine and lucidioline. Phytochemistry (Oxford) 34, 1425-8. Contact: Cordell, Geoffrey A.; Program Collaborative Research Pharmaceutical Sci., Dep. Med. Chem. Pharmacognosy, Coll. Pharm., Univ. Illinoi Chicago, Chicago, IL 60612, USA

 

Ashani Y, Peggins JO, III, Doctor BP (1992) Mechanism of Inhibition of Cholinesterases by Huperzine A. Biochemical and Biophysical Research Communications 184, 719-26. Contact: ASHANI Y ; WALTER REED ARMY INST RES, WASHINGTON, DC 20307, USA

 

Kozikowski AP, Thiels E, Tang XC, Hanin I (1992) Huperzine A: A possible lead structure in the treatment of Alzheimer's disease. In 'Advances in Medicinal Chemistry' pp. 175-205. (JAI Press Inc.; Jai Press Inc.)

 

Kozikowski AP, Yamada F, Pang YP (1992) Synthesis and 2d Nmr Analysis of a Cyclopropane Containing Analogue of Huperzine A. Tetrahedron Letters 33, 2653-6. Contact: KOZIKOWSKI A P ; NEUROCHEMISTRY RES, MAYO CLINIC JACKSONVILLE, 4500 SAN PABLO ROAD, JACKSONVILLE, FLA 32224, USA

 

Kartesz JT, Gandhi KN (1991) Nomenclatural Notes for the North American Flora V. Phytologia 70, 194-208. Contact: KARTESZ J T ; NC BOTANICAL GARDEN, DEP BIOLOGY, COKER HALL, UNIV NC, CHAPEL HILL, NC 27599-3280, USA

 

Kozikowski AP, Xia Y, Reddy ER, Tuckmantel W, Hanin I, Tang XC (1991) Synthesis of Huperzine a and Its Analogues and Their Anticholinesterase Activity. Journal of Organic Chemistry 56, 4636-45. Contact: KOZIKOWSKI A P ; NEUROCHEM RES, MAYO CLIN JACKSONVILLE, 4500 SAN PABLO RD, JACKSONVILLE, FLA 32224, USA

 

Zhang RW, Tang XC, Han YY, Sang GW, Zhang YD, Ma YX, Zhang CL, Yang RM (1991) Drug Evaluation of Huperzine a in the Treatment of Senile Memory Disorders. Acta Pharmacologica Sinica 12, 250-2. Contact: ZHANG R-W ; ZHEJIANG ACAD MED SCI, HANGZHOU 310013, CHINA

 

Zhu XZ (1991) Development of Natural Products as Drugs Acting on Central Nervous System. Memorias do Instituto Oswaldo Cruz 86, 173-6. Contact: ZHU X-Z; DEP PHARMACOL, SHANGHAI INST MATERIA MED, CHIN ACAD SCI, 319 YUE-YANG RD, SHANGHAI 200031, CHINA

 

Kozikowski AP, Reddy ER, Miller CP (1990) A Simplified Route to a Key Intermediate in the Synthesis of the Chinese Nootropic Agent Huperzine A. Journal of the Chemical Society Perkin Transactions I, 195-7. Contact: KOZIKOWSKI A P ; DEP CHEM BEHAVIORAL NEUROSCI, CHEVRON SCI CENT, UNIV PITTSBURGH, PITTSBURGH, PA 15260, USA

 

Guan LC, Chen SS, Lu WH, Tang XC (1989) Effects of Huperzine a on Electroencephalography Power Spectrum in Rabbits. Acta Pharmacologica Sinica 10, 496-500. Contact: GUAN L-C ; INST PSYCOL, CHINESE ACADEMY SCI, BEIJING 100012, CHINA

 

Hu DH, Dong HJ (1989) Effect of Huperzine a on the Function of Skeletal Muscle and Its Efficacy in Treating Experimental Autoimmune Myasthenia Gravis Eamg in Rabbits. Zhongguo Yaolixue Yu Dulixue Zazhi 3, 12-7. Contact: HU D-H ; INST PHARMACOLOGY AND TOXICOLOGY, ACADEMY MILITARY, MEDICAL SCI, BEIJING 100850

 

Xia Y, Reddy ER, Kozikowski AP (1989) Synthesis of the Benzenoid Analogue of the Chinese Nootropic Agent Huperzine A. Tetrahedron Letters 30, 3291-4. Contact: XIA Y ; DEP CHEM, UNIV PITTSBURGH, CHEVRON SCI CENT, PITTSBURGH, PA 15260, USA

 

Li J, Han YY, Liu JS (1988) Studies on Triterpenoids of Huperzia-Serrata Thunb. Yaoxue Xuebao 23, 549-52. Contact: LI J ; ZHEJIANG PROVINCIAL ACAD MED, HANGZHOU

 

Lu WH, Shou J, Tang XC (1988) Improving Effect of Huperzine a on Discrimination Performance in Aged Rats and Adult Rats with Experimental Cognitive Impairment. Acta Pharmacologica Sinica 9, 11-5. Contact: LU W-H ; SHANGHAI INST MATERIA MED, CHINESE ACAD SCI, SHANGHAI 200031

 

Wang YE, Feng J, Lu WH, Tang XC (1988) Pharmacokinetics of Huperzine a in Rats and Mice. Acta Pharmacologica Sinica 9, 193-6. Contact: WANG Y-E ; SHANGHAI INST MATERIA MED, CHINESE ACAD SCI, SHANGHAI 200031

 

Yuan SQ, Wei TT (1988) Studies on the Alkaloids of Huperzia-Serrata Thunb. Trev. Yaoxue Xuebao 23, 516-20. Contact: YUAN S Q ; ACAD MILITARY MED SCI, BEIJING

 

Zhu XD, Tang XC (1988) Improvement of Impaired Memory in Mice by Huperzine a and Huperzine B. Acta Pharmacologica Sinica 9, 492-7. Contact: ZHU X-D ; SHANGHAI INST MATERIA MEDICA, CHIN ACAD SCI, SHANGHAI 200031

 

Chen SM, Xue ZG (1987) The Effect of Fordine on Learning and Memory in Rats. Yaoxue Xuebao 22, 801-6. Contact: CHEN S-M ; DEP MATERIA MED PHARMACOL, CHINESE PLA GENERAL HOSP, BEIJING

 

Xu H, Tang XC (1987) Cholinesterase Inhibition by Huperzine B. Acta Pharmacologica Sinica 8, 18-22. Contact: XU H ; SHANGHAI INST MATERIA MED, CHINESE ACADEMY SCI, SHANGHAI 200031

 

Yan XF, Lu WH, Lou WJ, Tang XC (1987) Effects of Huperzine a and B on Skeletal Muscle and Electroencephalogram. Acta Pharmacologica Sinica 8, 117-23. Contact: YAN X-F ; SHANGHAI INST OF MATERIA MED, CHINESE ACADEMY OF SCI, SHANGHAI 200031

 

Zhu XD, Tang XC (1987) Facilitatory Effects of Huperzine a and B on Learning and Memory of Spatial Discrimination in Mice. Yaoxue Xuebao 22, 812-7. Contact: ZHU X-D ; SHANGHAI INST MATERIA MED, CHINESE ACAD SCI, SHANGHAI

 

Liu JS, Zhu YL, Yu CM, Zhou YZ, Han YY, Wu FW, Qi BF (1986) The Structure of Huperzine a and B Two New Alkaloids Exhibiting Marked Anticholinesterase Activity. Canadian Journal of Chemistry 64, 837-9. Contact: LIU J-S ; SHANGHAI INST MATERIA MED, ACAD SINICA, SHANGHAI 200031, CHINA

 

Tang XC, Han YF, Chen XP, Zhu XD (1986) Effects of Huperzine a on Learning and Retrieval Process of Discrimination Performance in Rats. Acta Pharmacologica Sinica 7, 507-11. Contact: TANG X-C ; SHANGHAI INST MATERIA MED, CHINESE ACAD SCI, SHANGHAI 200031

 

Wang YE, Yue DX, Tang XC (1986) Anticholinesterase Activity of Huperzine A. Acta Pharmacologica Sinica 7, 110-3. Contact: WANG Y-E ; SHANGHAI INST MATERIA MEDICA, CHINESE ACAD SCI, SHANGHAI 200031

 

Sen T, Sen U (1978) Morphology Anatomy and Taxonomy of Lycopodiaceae of the Darjeeling Himalayas India. Fern Gazette 11, 413-27. Contact: SEN T ; DEP BOT, KALYANI UNIV, KALYANI 741235, KARNATAKA, INDIA

 

Rothmaler W (1944) Pteridophyten-Studien. I. Rep Spec Nov Reg Veg 54, 55-82.

 

 

 

 


Rural Industries Research and Development Corporation (RIRDC) Home Page

RIRDC New Plant Products
Home Page

RIRDC New Plant Products
Research Reports

RIRDC New Rural Industries
Handbook Contents


All information is included in good faith but this website does not warrant or guarantee the accuracy of any information on these pages, nor does the website accept responsibility for any loss arising from the use of this information.  Views and opinions are those of the authors themselves.  Grateful acknowledgment is made to the following for plant names: Australian Plant Name Index, Australian National Herbarium http://www.anbg.gov.au/cpbr/databases/apni-search-full.html; The International Plant Names Index, Royal Botanic Gardens, Kew/Harvard University Herbaria/Australian National Herbarium http://www.ipni.org/index.html; Plants Database, United States Department of Agriculture, National Resources Conservation Service http://plants.usda.gov/; DJ Mabberley (1997) The Plant Book, Cambridge University Press (Second Edition); JH Wiersma and B Leon (1999) World Economic Plants, CRC Press; RJ Hnatiuk (1990) Census of Australian Vascular Plants, Australian Government Publishing Service.


Contact: Webmaster, Australian New Crops Website
australiannewcrops@gmail.com

Latest update 31 January 2008 by: ANCW