Source: AGRICOLA database (1970-1996)

Fukuda, K., Y. Hibiya, et al. (2000). Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. Biochemical Pharmacology. [print] 60(4): 595-600. {a} Department of Oriental Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500-8705, Japan

Patel, N. M., S. Nozaki, et al. (2000). Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. Oncogene . [print] 19(36): 4159-4169. {a} Indiana Cancer Research Institute, 1044 West Walnut St., R4-202, Indianapolis, IN, 46202, USA

Stingeni, L. and P. Lisi (2000). Preliminary experience with a new "Mediterranean" Compositae mix. Contact Dermatitis. [print] November 43(5): 313-314. {a} Allergologic and Environmental Dermatology Unit, Department of Medical and Surgical Specialities, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy

Brown, A. M. G., C. M. Edwards, et al. (1999). Sexual hybrids of Tanacetum: Biochemical, cytological and pharmacological characterization. Journal of Experimental Botany 50(333): 435-444. {a} Plant Science Division, School of Biological Sciences, University Park, University of Nottingham, Nottingham, NG7 2RD, UK

Christensen, L. P., H. B. Jakobsen, et al. (1999). Airborne Compositae dermatitis: Monoterpenes and no parthenolide are released from flowering Tanacetum parthenium (feverfew) plants. Archives of Dermatological Research. July Aug 291(7-8): 425-431. {a} Department of Dermatology, Odense University Hospital, DK-5000, Odense, Denmark

Galal, A. M., A. R. S. Ibrahim, et al. (1999). Microbial transformation of parthenolide. Phytochemistry Oxford. July 51(6): 761-765. {a} Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

Grice, I. D., M. Salzmann, et al. (1999). Simultaneous determination of aldrin, dieldrin, endrin, heptachlor, and p,p'-DDT in medicinal plant extracts using a novel high performance liquid chromatography method. Journal of Liquid Chromatography and Related Technologies. Sept. 22(15): 2337-2344. {a} School of Health Science, Griffith University, Gold Coast, QLD, 4217, Australia

Kulkarni, S. K. and N. K. Jain (1999). Feverfew: Ancient remedy for multiple disorders. Drugs of the Future. Dec. 24(12): 1339-1343. {a} Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India

Ross, J. J., J. T. Arnason, et al. (1999). Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion. Planta Medica. March 65(2): 126-129. {a} Ottawa Regional Cancer Centre, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada

Stingeni, L., E. Agea, et al. (1999). T-lymphocyte cytokine profiles in Compositae airborne dermatitis. British Journal of Dermatology. Oct. 141(4): 689-693. {a} Section of Allergic and Environmental Dermatology, Department of Medical and Surgical Specialities, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy

Sy, L. K. and G. D. Brown (1999). Coniferaldehyde derivatives from tissue culture of Artemisia annua and Tanacetum parthenium. Phytochemistry Oxford 50(5): 781-785. {a} Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong, China

Williams, C. A., J. B. Harborne, et al. (1999). Variations in lipophilic and polar flavonoids in the genus Tanacetum. Phytochemistry Oxford. Dec. 52(7): 1301-1306. {a} Department of Botany, University of Reading, Reading, RG6 6AS, UK

Williams, C. A., J. B. Harborne, et al. (1999). The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Phytochemistry Oxford. June 51(3): 417-423. {a} Department of Botany, The University of Reading, Reading, RG6 6AS, UK

Zhou, J. Z., X. Kou, et al. (1999). Rapid extraction and high-performance liquid chromatographic determination of parthenolide in feverfew (Tanacetum parthenium). Journal of Agricultural and Food Chemistry 47(3): 1018-1022. {a} Department of Research and Development, Nature's Sunshine Products, Inc., 1655 North Main Street, Spanish Fork, UT, 84660, USA

Schinella, G. R., R. M. Giner, et al. (1998). Anti-inflammatory effects of South American Tanacetum vulgare. Journal of Pharmacy and Pharmacology 50(9): 1069-1074. {a} Av. V. A. Estelles s/n, 46100 Burjassot, Valencia, Spain

Vogler, B. K., M. H. Pittler, et al. (1998). Feverfew as a preventive treatment for migraine: A systematic review. Cephalalgia 18(10): 704-708. {a} Dep. Complementary Med., Sch. Postgrad. Med. Health Sci., Univ. Exeter, 25 Victoria Park Rd., Exeter EX2 4NT, UK

Brown, A. M. G., C. M. Edwards, et al. (1997). Pharmacological activity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.): Assessment by inhibition of human polymorphonuclear leukocyte chemiluminescence in-vitro. Journal of Pharmacy and Pharmacology 49(5): 558-561. {a} Dep. Life Sci., Univ. Nottingham, University Park, Nottingham NG7 2RD, UK

Hendriks, H., W. Y. Anderson, et al. (1997). The content of parthenolide and its yield per plant during the growth of Tanacetum parthenium. Planta Medica 63(4): 356-359. {a} Dep. Pharm. Biol., Univ. Centre Pharm., Groningen Inst. Drug Studies, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

Kalodera, Z., S. Pepeljnjak, et al. (1997). Chemical composition and antimicrobial activity of Tanacetum parthenium essential oil. Pharmazie 52(11): 885-886. {a} Dep. Pharmacognosy, Univ. Zagreb, Marulicev trg 20/II, HR-10000 Zagreb, Croatia

Kisiel, W. and A. Stojakowska (1997). A sesquiterpene coumarin ether from transformed root of Tanacetum parthenium. Phytochemistry Oxford 46(3): 515-516. {a} Dep. Phytochemistry, Inst. Pharmacology, Polish Academy Sci., PL-31-343 Krakow, Poland

Milbrodt, M., F. Schroeder, et al. (1997). 3,4-beta-Epoxy-8-deoxycumambrin B, a sesquiterpene lactone from Tanacetum parthenium. Phytochemistry Oxford 44(3): 471-474. {a} Inst. Org. Chemie, Univ. Hamburg, D-20146 Hamburg, Germany

Murch, S. J., C. B. Simmons, et al. (1997). Melatonin in feverfew and other medicinal plants. Lancet North American Edition 350(9091): 1598-1599. {a} Dep. Horticultural Sci., Univ. Guelph, Guelph, ON N1G 2W1, Canada

Bejar, E. (1996). Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin. Journal of Ethnopharmacology 50(1): 1-12. Rees-Stealy Res. Foundation Lab., 2001 Fourth Ave., San Diego, CA 92101-2303, USA

Brown, A. M. G., K. C. Lowe, et al. (1996). Feverfew (Tanacetum parthenium L.): Tissue culture and parthenolide synthesis. Plant Science Shannon 116(2): 223-232. {a} Plant Genetic Manipulation Group, Dep. Life Sci., Univ. Nottingham, University Park, Nottingham NG7 2RD, UK

Brown, A. M. G., K. C. Lowe, et al. (1996). Comparison of extraction procedures for parthenolide in Tanacetum parthenium. Phytochemical Analysis 7(2): 86-91. {a} Plant Genetic Manipulation Group, Dep. Life Sci., Univ. Nottingham, Nottingham NG7 2RD, UK

Dragland, S. (1996). Content of cadmium and lead in chamomile (Chamomilla recutitia L.) and feverfew (Tanacetum parthenium L.) grown in different parts of Norway. Norsk Landbruksforsking 10(3-4): 181-188. Norwegian Crop Res. Inst., Apelsvoll Res. Centre, Div. Kise, Nes pa Hedmark, Norway

Hendriks, H., R. Bos, et al. (1996). The essential oil of Tanacetum parthenium (L.) Schultz-Bip. Flavour and Fragrance Journal 11(6): 367-371. {a} Dep. Pharmaceutical Biol., Univ. Centre Pharmacy, Groningen Inst. Drug Studies, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands

Hwang, D., N. H. Fischer, et al. (1996). Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochemical and Biophysical Research Communications 226(3): 810-818. {a} Pennington Biomed. Res. Cent., La. State Univ., 6400 Perkins Rd., Baton Rouge, LA 70808, USA

Izco, J. (1996). Species composition of the "rose water" traditionally prepared on Saint John's Eve in Galicia (Northwest Spain). Anales de la Real Academia de Farmacia 62(2): 223-238. Lab. Botanica, Dep. Biologia Vegetal, Univ. Santiago, E-15706 Santiago de Compostela, Spain

Kalodera, Z., S. Pepeljnjak, et al. (1996). The antimicrobial activity of Tanacetum parthenium extract. Pharmazie 51(12): 995-996. {a} Dep. Pharmacognosy, Univ. Zagreb, Marulicev trg 20/II, 10000 Zagreb, Croatia

Wilkomirski, B. and B. Dubielecka (1996). Sterol content as a similarity marker of different organs of two varieties of Chrysanthemum parthenium. Phytochemistry Oxford 42(6): 1603-1604. {a} Dep. Plant Systematics and Geography, Univ. Warsaw, 00-478 Warszawa, Al. Ujazdowskie 4, Poland

Juan, A., L. Serra, et al. (1995). Fragmenta chorologica occidentalia, 5462-5478. Anales del Jardin Botanico de Madrid 53(1): 111-112. Dep. Ciencias Ambientales Recursos Nat., Univ. Alicante, Apartado 99, E-03080 Alicante, Spain

Robles, M., M. Aregullin, et al. (1995). Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Medica 61(3): 199-203. {a} L. H. Bailey Hortorium, Div. Biological Sci., Cornell Univ., Ithaca, New York 14853-2703, USA

Williams, C. A., J. R. S. Hoult, et al. (1995). A biologically active lipophilic flavonol from Tanacetum parthenium. Phytochemistry Oxford 38(1): 267-270. {a} Dep. Botany, Sch. Plant Sci., Univ. Reading, Whiteknights, Reading RG6 2AS, Berkshire, UK

Hay, A. J. B., M. Hamburger, et al. (1994). Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions. British Journal of Pharmacology 112(1): 9-12. {a} Pharmacol. Group, King's College London, Manresa Rd., London SW3 6LX, UK

Avila, A. J. G., L. J. L. Munoz, et al. (1993). In vitro antimicrobial activity of various plant extracts used by Purepecha against some Enterobacteriaceae. International Journal of Pharmacognosy 31(1): 61-64. Proyect Natural Products Res., ENEP-Iztacale, UNAM. Av. Barrios s/n, Los Reyes Iztacala, C.P. 54090, Tlalnepantla, Edo. Mexico

Baltisberger, M. (1993). Cytological investigations on Compositae for Albania. Candollea 48(2): 437-448. Geobotanisches Institut ETH, Zollikerstrasse 107, CH-8008 Zurich, Switzerland

Barsby, R. W. J., D. W. Knight, et al. (1993). A chloroform extract of the herb feverfew blocks voltage-dependent potassium currents recorded from single smooth muscle cells. Journal of Pharmacy and Pharmacology 45(7): 641-645. {a} Pharmacology Group, Div. Biomedical Scineces, King's Coll. London, Manresa Road, London SW3 6LX, UK

Kawabata, K., K. Sumikawa, et al. (1993). Effect of local anaesthetics on the stimulus-secretion coupling in bovine adrenal chromaffin cells. Journal of Pharmacy and Pharmacology 45(7): 632-635. {a} Dep. Anesthesiology, Osaka Univ. Med. Sch., 1-1-50 Fukushima-ku, Fukushima, Osaka 553, Japan

Smith, R. M. and M. D. Burford (1993). Comparison of flavanoids in feverfew varieties and related species by principal components analysis. Chemometrics and Intelligent Laboratory Systems 18(3): 285-291. {a} Dep. Chem., Loughborough Univ. Technol., Loughborough, Leics. LE11 3TU, UK

Wegener, H. C. and S. Schwarz (1993). Antibiotic-resistance and plasmids in Staphylococcus hyicus isolated from pigs with exudative epidermitis and from healthy pigs. Veterinary Microbiology 34(4): 363-372. Natl. Vet. Lab., 27 Bulowsvej, DK-1790 Copenhagen V, Denmark

Barsby, R. W. J., U. Salan, et al. (1992). Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. Journal of Pharmacy and Pharmacology 44(9): 737-740. {a} Pharmacol. Group, King's Coll. London, Manresa Rd., London SW3 6LX, UK

Dolman, D. M., D. W. Knight, et al. (1992). A quantitative method for the estimation of parthenolide and other sesquiterpene lactones containing alpha-methylenebutyrolactone functions present in Feverfew, Tanacetum parthenium. Phytochemical Analysis 3(1): 26-31.

Heptinstall, S., D. V. C. Awang, et al. (1992). Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.): Estimation of commercial and authenticated feverfew products. Journal Of Pharmacy And Pharmacology 44(5): 391-395.

Smith, R. M. and M. D. Burford (1992). Supercritical fluid extraction and gas chromatographic determination of the sesquiterpene lactone parthenolide in the medicinal herb feverfew (Tanacetum parthenium). Journal of Chromatography 627(1-2): 255-261. {a} Dep. Chem., Loughborough Univ. Technol., Loughborough, Leics, LE11 3TU, UK

Sumner, H., U. Salan, et al. (1992). Inhibition of 5-lipoxygenase and cyclooxygenase in leukocytes by feverfew: Involvement of sesquiterpene lactones and other components. Biochemical Pharmacology 43(11): 2313-2320.

Bruhl, J. J. and C. J. Quinn (1991). Floral morphology and a reassessment of affinities in the "Cotuleae" (Asteraceae). Australian Systematic Botany 4(4): 637-654.

Banthorpe, D. V. and G. D. Brown (1990). Growth and secondary metabolism in cell cultures of Tanacetum, Mentha and Anethum species in buffered media. Plant Science 67(1): 107-114.

Banthorpe, D. V., G. D. Brown, et al. (1990). Parthenolide and other volatiles in the flowerheads of Tanacetum parthenium (L.) Schultz Bip. Flavour And Fragrance Journal 5(3): 183-186.

Fontanel, D., S. Bizot, et al. (1990). Determination of parthenolide content in the chamomile Tanacetum parthenium (L.) Schulz-Bip by HPLC. Plantes Medicinales Et Phytotherapie 24(4): 231-237.

Banthorpe, D. V. and G. D. Brown (1989). Two unexpected coumarin derivatives from tissue cultures of Compositae species. Phytochemistry 28(11): 3003-3008.

Begley, M. J., M. J. Hewlett, et al. (1989). Revised structures for guaianolide alpha-methylenebutyrolactones from feverfew. Phytochemistry 28(3): 940-943.

Pattrick, M., S. Heptinstall, et al. (1989). Feverfew in rheumatoid arthritis: A double blind, placebo controlled study. Annals Of The Rheumatic Diseases 48(7): 547-549.

Murphy, J. J., S. Heptinstall, et al. (1988). Randomized double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet 2(8604): 189-192.

Pugh, W. J. and K. Sambo (1988). Prostaglandin synthetase inhibitors in feverfew. Journal Of Pharmacy And Pharmacology 40(10): 743-745.

Stefanovic, M., N. Ristic, et al. (1988). Biological activities of sesquiterpene lactones: Investigations of microbial activities of lactones isolated from the Yugoslav plant species of the genus Tanacetum L. (Chrysanthemum (family Compositae)). Bulletin De L'Academie Serbe Des Sciences Et Des Arts Classe Des Sciences Mathematiques Et Naturelles Sciences Naturelles(28): 23-40.

Hayes, N. A. and J. C. Foreman (1987). The activity of compounds extracted from feverfew on histamine release from rat mast cells. Journal Of Pharmacy And Pharmacology 39(6): 466-470.

O'Neill, L. A. J., M. L. Barrett, et al. (1987). Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect. British Journal Of Clinical Pharmacology 23(1): 81-83.

Capasso, F. (1986). The effect of an aqueous extract of Tanacetum parthenium on arachidonic acid metabolism by rat peritoneal leukocytes. Journal Of Pharmacy And Pharmacology 38(1): 71-72.

Johnson, E. S., N. P. Kadam, et al. (1985). Efficacy of feverfew (Tanacetum parthenium) as prophylactic treatment of migraine. British Medical Journal 291(6495): 569-573.

Awang, D. V. C., B. A. Dawson, et al. (1516). Parthenolide content of feverfew (Tanacetum parthenium) assessed by HPLC and proton NMR spectroscopy. Journal Of Natural Products 54(6): 1516-1521.

Heptinstall, S., A. White, et al. (1071). Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leukocytes. Lancet 1(8437): 1071-1074.

Marles, R. J., J. Kaminski, et al. (1044). A bioassay for inhibition of serotonin release from bovine platelets. Journal Of Natural Products 55(8): 1044-1056.

Stojakowska, A. and W. Kisiel Production of parthenolide in organ cultures of feverfew. Plant Cell Tissue and Organ Culture 47(2): 159-162. Dep. Phytochemistry, Inst. Pharmacology, Polish Academy Sci., Smetna 12, PL-31-343 Krakow, Poland